PNU-183792
Product Specifications
CAS Number
282536-25-8
Target
HSV
Related Pathways
Microbiology/Virology
Bioactivity
PNU-183792 is a 4-oxo-1,4-dihydroquinoline that acts as an orally active inhibitor of herpesvirus polymerases (HSV polymerases) . It exhibits broad-spectrum antiviral activity, with IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella-zoster virus, and 0.58 μM for herpes simplex virus (HSV) polymerase. PNU-183792 shows no activity against human α, γ, and δ polymerases but inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV) .
Smiles
O=C(NCC1=CC=C(Cl)C=C1)C2=CN(C3=CC=C(C=C3C2=O)CN4CCOCC4)C
Molecular Formula
C23H24ClN3O3
Molecular Weight
425.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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