SB-583355

Product Specifications

CAS Number

3040121-49-8

Target

GPCR

Related Pathways

Endocrinology/Hormones, GPCR/G Protein

Bioactivity

SB-583355 (Compound 56) is a potent G2A antagonist. It is synthesized through a Suzuki reaction of 4-methoxyphenylboronic acid with 3-bromo-4-hydroxybenzoic acid under specific conditions, followed by amide coupling. SB-583355 effectively blocks G2A activation mediated by 9-HOPE or T-10148 in CHO-K1 cells expressing human G2A. This compound is useful for investigating inflammation, myeloid leukemia, and neuropathic pain.

Smiles

OC=1C(=CC(C(N[C@@H](CC2=CC=CC=C2)C(NC3CCCCC3)=O)=O)=CC1)C4=CC=C(OC)C=C4

Molecular Formula

C29H32N2O4

Molecular Weight

472.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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