What is the catalog number for PROTAC EGFR degrader 12?

The catalog number for PROTAC EGFR degrader 12 is T211103.

What sizes are available for PROTAC EGFR degrader 12?

PROTAC EGFR degrader 12 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does PROTAC EGFR degrader 12 come in?

PROTAC EGFR degrader 12 is available in 2 different pack sizes.

Is PROTAC EGFR degrader 12 in stock?

PROTAC EGFR degrader 12 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PROTAC EGFR degrader 12?

PROTAC EGFR degrader 12 is manufactured by Molfinity.

What is the estimated delivery time for PROTAC EGFR degrader 12?

Estimated delivery time for PROTAC EGFR degrader 12 is approximately 10 business day(s), depending on your location.

PROTAC EGFR degrader 12

Product Specifications

CAS Number

2654821-05-1

Target

EGFR, PROTACs

Related Pathways

JAK/STAT signaling, Tyrosine Kinase/Adaptors, PROTAC, Angiogenesis

Bioactivity

PROTACEGFRdegrader 12 (example 1) is a PROTAC degrader that selectively targets and degrades mutant EGFR, with minimal effect on EGFRWT. It demonstrates an IC50 of less than 50 nM against EGFRL858R-T790M (NCI-H1975 cells), EGFRL858R (NCI-H3255 cells), and EGFRL858R-T790M-L797S (NCI-H1975+CS cells) .

Smiles

C(CC1(O)CCN(CC1)C2=C(F)C=C(N[C@@H]3C(=O)NC(=O)CC3)C=C2)(=O)N4CC5(CN(C5)C6=CC=C(C=C6)C=7C=C8C(=C(F)C7)CN(C(C(NC9=NC=CS9)=O)C%10=C%11N(C=N%10)CCC%11)C8=O)C4