Hsp90-IN-42

Hsp90-IN-42 (Compound 13l) is a potent inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 15.65 nM. It destabilizes the epidermal growth factor receptor (EGFR), inhibits the activation of the EGFR-Akt signaling pathway, induces G0/G1 phase arrest, and slightly triggers apoptosis in colorectal cancer cells, such as HT-29 cells. Additionally, Hsp90-IN-42 suppresses cell proliferation and migration by downregulating CDK12, CDK13, and Bcl-2 protein expression while upregulating Bax protein expression. This compound shows potential for research in colorectal cancer.