What is the catalog number for WZH-17-002?

The catalog number for WZH-17-002 is T211075.

What sizes are available for WZH-17-002?

WZH-17-002 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does WZH-17-002 come in?

WZH-17-002 is available in 2 different pack sizes.

Is WZH-17-002 in stock?

WZH-17-002 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures WZH-17-002?

WZH-17-002 is manufactured by Molfinity.

What is the estimated delivery time for WZH-17-002?

Estimated delivery time for WZH-17-002 is approximately 10 business day(s), depending on your location.

WZH-17-002

Product Specifications

Target

PROTACs, Akt, ERK, ALK

Related Pathways

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Angiogenesis, MAPK, Tyrosine Kinase/Adaptors, PROTAC

Bioactivity

WZH-17-002 is an ALKPROTAC degrader based on WZH-15-125, with a DC50 of 25 nM. This compound enhances the efficacy against ALK mutations that confer resistance to Lorlatinib. Moreover, WZH-17-002 significantly reduces resistance in ALK fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196M xenograft mouse models.