CDK-IN-18
Product Specifications
CAS Number
2531743-46-9
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant, and selective inhibitor of CDK2, CDK4, and CDK6. It hinders the activity of cyclin-CDK complexes, preventing the phosphorylation of retinoblastoma protein (pRb), and thereby blocks the transition of cells from the G1 phase to the S phase. CDK-IN-18 shows potential for cancer research, such as in breast cancer (particularly hormone receptor-positive, HER2-negative types), lung cancer, and colorectal cancer.
Smiles
C(C)(C)C1=C2N(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5C(=O)C[C@@H](N(C)C)CC5)=NC=C3)N=C1
Molecular Formula
C26H30N8O
Molecular Weight
470.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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