What is the catalog number for OXPHOS-IN-2?

The catalog number for OXPHOS-IN-2 is T211046.

What sizes are available for OXPHOS-IN-2?

OXPHOS-IN-2 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does OXPHOS-IN-2 come in?

OXPHOS-IN-2 is available in 2 different pack sizes.

Is OXPHOS-IN-2 in stock?

OXPHOS-IN-2 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures OXPHOS-IN-2?

OXPHOS-IN-2 is manufactured by Molfinity.

What is the estimated delivery time for OXPHOS-IN-2?

Estimated delivery time for OXPHOS-IN-2 is approximately 10 business day(s), depending on your location.

OXPHOS-IN-2

Product Specifications

Target

AMPK, Apoptosis, OXPHOS, Mitochondrial Metabolism, Nrf2, ROS

Related Pathways

Immunology/Inflammation, Metabolism, Apoptosis, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic

Bioactivity

OXPHOS-IN-2 is an orally active inhibitor of OXPHOS, demonstrating potent inhibitory effects in PC9 cells (IC50= 12.3 nM) and Bxpc-3 cells (IC50= 250 nM in glucose medium, IC50= 17.5 nM in galactose medium) . It modulates the NADH/NAD+ ratio and decreases ATP levels. OXPHOS-IN-2 induces apoptosis in tumor cells by activating reactive oxygen species (ROS) and downregulating Nrf2 levels. This compound is applicable for research in cancers such as non-small cell lung cancer and pancreatic cancer.