SB-T-101141

SB-T-101141 is a novel taxane drug effective in inducing atypical ferroptosis, thereby overcoming resistance of breast cancer to Paclitaxel. It promotes the generation of iron ions, ferrous ions, and reactive oxygen species (ROS) . SB-T-101141 stably binds to KHSRP, inhibiting the expression of the iron-dependent CISD1 related to iron homeostasis. It synergistically enhances the activation of the iron-dependent JNK and PERK pathways through KHSRP. SB-T-101141 inhibits breast tumor growth in MCF-7 (PR) /MDA-MB-231 (PR) or KHSRP knockout MCF-7 xenograft mouse models.

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