CL5D
Product Specifications
CAS Number
2488745-53-3
Target
Sirtuin
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
CL5D is an activator of the protein deacetylase SIRT6. It significantly enhances the deacetylase activity and catalytic efficiency of SIRT6. CL5D modulates SIRT6 activity by promoting its conformational changes, particularly relying on the Arg-65 residue. This compound can be used to study the activation mechanism of SIRT6 and its roles in metabolism, DNA repair, and aging.
Smiles
O=C(O)C1=CC=C2C(=O)N(C(=O)C2=C1)C3=CC=C(C(Cl)=C3)N(C(=O)C=4C(Cl)=CC(Cl)=CC4Cl)C(=O)C=5C(Cl)=CC(Cl)=CC5Cl
Molecular Formula
C29H11Cl7N2O6
Molecular Weight
731.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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