FGFR2/3-IN-3
Product Specifications
CAS Number
3069945-78-1
Target
Cytochromes P450, FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Metabolism
Bioactivity
FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50 values of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), displaying efficacy against both wild-type and mutant FGFR3. It exhibits low CYP3A4 inhibition and minimal hERG toxicity. By inhibiting mutant FGFR3-mediated pathways, FGFR2/3-IN-3 improves chondrocyte proliferation and differentiation imbalances, promoting bone growth. In a dwarfism mouse model, it demonstrates growth-promoting effects, indicating potential for treating bone development disorders such as achondroplasia (ACH) .
Smiles
O([C@H](C)C=1C(Cl)=CN=CC1Cl)C=2C=C3C(=NNC3=CC2C)C=4C=C(F)C(=NC4)C5=CN(CC(C)(C)O)N=C5C
Molecular Formula
C28H27Cl2FN6O2
Molecular Weight
569.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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