FKBP12 ligand-3
Product Specifications
CAS Number
3036374-26-9
Target
FKBP
Related Pathways
Apoptosis|||Immunology/Inflammation|||Autophagy
Bioactivity
FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. It is utilized to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching drugs intracellularly through the "CellTrap" effect to form an FKBP12-ligand-BRD4 ternary complex. This complex inhibits BRD4, reducing the expression of BRD4 target genes such as MYC, leading to tumor cell death. FKBP12 ligand-3 can be applied in selective cancer research based on differences in intracellular presenter protein levels.
Smiles
S(=O)(=O)(N1[C@]2([C@@H](COCC#C)CN([C@@H](C)C3=CC=CC=N3)C(=O)[C@@]1(CCC2)[H])[H])C4=CC(Cl)=CC(Cl)=C4
Molecular Formula
C25H27Cl2N3O4S
Molecular Weight
536.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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