RJG-2036
Product Specifications
CAS Number
2851993-73-0
Target
Prostaglandin Receptor
Related Pathways
Immunology/Inflammation, GPCR/G Protein
Bioactivity
RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2) with an IC50 of 100 nM. It effectively inhibits NADPH-dependent reduction reactions, significantly reducing the secretion of inflammatory factors such as TNF-α and the release of various pro-inflammatory eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 shows promise for research in inflammatory diseases.
Smiles
O=C(C1=CC=CC(=C1)S(=O)(=O)N2N=CN=C2)N3CCN(C=4C=CC=CC4OC)CC3
Molecular Formula
C20H21N5O4S
Molecular Weight
427.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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