What is the catalog number for AH001?

The catalog number for AH001 is T210940.

What sizes are available for AH001?

AH001 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does AH001 come in?

AH001 is available in 2 different pack sizes.

AH001 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AH001?

AH001 is manufactured by Molfinity.

What is the estimated delivery time for AH001?

Estimated delivery time for AH001 is approximately 10 business day(s), depending on your location.

AH001

Product Specifications

CAS Number

1456769-95-1

Target

Ras

Related Pathways

MAPK

Bioactivity

AH001 is an orally active compound that binds to a concealed pocket near GDP within RhoA, exhibiting a binding affinity of 73.16 nM. By interacting with GDP, AH001 stabilizes the interaction between RhoA and its endogenous inhibitor, RhoGDIα. This compound reduces nuclear translocation of downstream MRTFA and downregulates fibrosis/hypertrophy-related proteins. AH001 alleviates myocardial remodeling in various heart failure animal models and 3D cardiac tissue models. Its cardioprotective effects are mediated through the RhoA-RhoGDIα axis, effectively inhibiting downstream RhoA activation signals.