WZH-15-125
Product Specifications
CAS Number
2845188-22-7
Target
Ligands for Target Protein for PROTAC, ALK
Related Pathways
Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors
Bioactivity
WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.
Smiles
O=S(=O)(N(C1=C2OCCOC2=CC=C1NC3=NC(=NC=C3Br)NC=4C=C(C(=CC4OC)N5CCC(N6CCN(C)CC6)CC5)CC)C)C
Molecular Formula
C33H45BrN8O5S
Molecular Weight
745.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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