What is the catalog number for PIM-1/HDAC-IN-2?

The catalog number for PIM-1/HDAC-IN-2 is T210915.

What sizes are available for PIM-1/HDAC-IN-2?

PIM-1/HDAC-IN-2 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does PIM-1/HDAC-IN-2 come in?

PIM-1/HDAC-IN-2 is available in 2 different pack sizes.

Is PIM-1/HDAC-IN-2 in stock?

PIM-1/HDAC-IN-2 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PIM-1/HDAC-IN-2?

PIM-1/HDAC-IN-2 is manufactured by Molfinity.

What is the estimated delivery time for PIM-1/HDAC-IN-2?

Estimated delivery time for PIM-1/HDAC-IN-2 is approximately 10 business day(s), depending on your location.

PIM-1/HDAC-IN-2

Product Specifications

Target

Pim, PARP, Apoptosis, HDAC

Related Pathways

DNA Damage/DNA Repair, Apoptosis, JAK/STAT signaling, Chromatin/Epigenetic

Bioactivity

PIM-1/HDAC-IN-2 is a potent dual inhibitor of PIM/HDAC, exhibiting an IC50 value of 0.11 μM. It synergistically impedes cell proliferation through the inhibition of PIM1 kinase and the selective suppression of HDAC6. This compound effectively induces PARP cleavage, causing cell cycle arrest in the G1 phase and reducing S phase cells. PIM-1/HDAC-IN-2 demonstrates significant anticancer activity in the MV4-11 tumor xenograft model, with minimal toxicity.