KI-TOX-A3
Product Specifications
CAS Number
1351116-34-1
Target
Histone Acetyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 ?M for the TOX-KAT7 interaction. It promotes proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses CD8+ T cell exhaustion, and inhibits proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 holds potential for research in hematological malignancies, including T-ALL.
Smiles
N#CC1=C(N=C2C=3C=CC(O)=CC3CC2=C1C=4OC(=CC4)CO)N
Molecular Formula
C18H13N3O3
Molecular Weight
319.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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