SGC-NSP2hel-1

SGC-NSP2hel-1 (RA-0188293) is a potent and selective oral inhibitor of the nsP2 helicase, with a CC50 greater than 250 μM and a selectivity index over 4000. It exhibits broad-spectrum activity against various alphaviruses. In preclinical small animal models of chikungunya virus (CHIKV) disease, SGC-NSP2hel-1 reduces viral replication and limits virus-induced pathology by forming a stable complex with nsP2 and ATP.