NF-?B degrader 1
Product Specifications
Target
NF-?B
Related Pathways
NF-?B
Bioactivity
NF-?Bdegrader 1 (Compound MD-1) is an NF-?B1p105 subunit degrader. It exhibits anti-inflammatory properties, with an IC50 of 2.02 ?M for inhibiting TNF-? and 5.40 ?M for inhibiting NO. NF-?Bdegrader 1 induces p105 degradation via the Cullin-RING ligase (CRL) SCFBTCP, thereby inhibiting NF-?B transcriptional activity. This compound shows potential for research in inflammation-related diseases.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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