NF-?B degrader 1

NF-?Bdegrader 1 (Compound MD-1) is an NF-?B1p105 subunit degrader. It exhibits anti-inflammatory properties, with an IC50 of 2.02 ?M for inhibiting TNF-? and 5.40 ?M for inhibiting NO. NF-?Bdegrader 1 induces p105 degradation via the Cullin-RING ligase (CRL) SCFBTCP, thereby inhibiting NF-?B transcriptional activity. This compound shows potential for research in inflammation-related diseases.