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RUNX1/ETO-IN-1

Product Specifications

CAS Number

923865-06-9

Target

Apoptosis|||Others

Related Pathways

Others|||Apoptosis

Bioactivity

RUNX1/ETO-IN-1 is an inhibitor targeting the oncogenic fusion protein RUNX1-ETO, specifically affecting the NHR2 oligomerization domain. It binds directly to NHR2 (KD, app = 39 ?M) . By inducing apoptosis and promoting differentiation, RUNX1/ETO-IN-1 exhibits antileukemic activity in RUNX1/ETO translocation acute myeloid leukemia (AML) cells. Its near-neutral charge under physiological pH conditions grants it excellent cell membrane permeability.

Smiles

O=C1C=C(N=C2SC=C(N12)C)CNC(C3=CC=C4OCCCOC4=C3)C(C)C

Molecular Formula

C21H25N3O3S

Molecular Weight

399.51

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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