RUNX1/ETO-IN-1
Product Specifications
CAS Number
923865-06-9
Target
Apoptosis|||Others
Related Pathways
Others|||Apoptosis
Bioactivity
RUNX1/ETO-IN-1 is an inhibitor targeting the oncogenic fusion protein RUNX1-ETO, specifically affecting the NHR2 oligomerization domain. It binds directly to NHR2 (KD, app = 39 ?M) . By inducing apoptosis and promoting differentiation, RUNX1/ETO-IN-1 exhibits antileukemic activity in RUNX1/ETO translocation acute myeloid leukemia (AML) cells. Its near-neutral charge under physiological pH conditions grants it excellent cell membrane permeability.
Smiles
O=C1C=C(N=C2SC=C(N12)C)CNC(C3=CC=C4OCCCOC4=C3)C(C)C
Molecular Formula
C21H25N3O3S
Molecular Weight
399.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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