CDK6/PIM1-IN-1 hydrochloride
Product Specifications
CAS Number
2677026-15-0
Target
Apoptosis, Pim, CDK
Related Pathways
Cell Cycle/Checkpoint, Chromatin/Epigenetic, Apoptosis, JAK/STAT signaling
Bioactivity
CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual inhibitor of CDK6 and PIM1, with IC50 values of 39 nM and 88 nM, respectively. It also inhibits CDK4 with an IC50 of 3.6 nM. This compound significantly suppresses the proliferation of acute myeloid leukemia (AML) cells, arrests the cell cycle at the G1 phase, and induces apoptosis. CDK6/PIM1-IN-1 hydrochloride demonstrates anti-AML activity.
Smiles
Cl.FC1=CN=C(N=C1C=2C=CC=3N=CC(=NC3C2)N(CC)CC)NC4=NC=C(C=C4)N5CCNCC5
Molecular Formula
C25H29ClFN9
Molecular Weight
510.01
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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