PROTAC JAK2 degrader-1
Product Specifications
Target
STAT, JAK
Related Pathways
JAK/STAT signaling, Stem Cells, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
PROTAC JAK2 degrader-1 (Compound 10i) is a JAK2 PROTAC degrader with a DC50 of 27.35 nM against JAK2V617F. It facilitates the ubiquitination and degradation of JAK2. This compound also inhibits the phosphorylation of JAK2, STAT3, and STAT5, and is applicable in the study of myeloproliferative neoplasms.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6314066-01 0.2 mL
KLHDC1, NT (KLHDC1, Kelch domain-containing protein 1) (Azide free) (HRP)
Sign In for Pricing
View Details MBS6314066-02 5x 0.2 mL
KLHDC1, NT (KLHDC1, Kelch domain-containing protein 1) (Azide free) (HRP)
Sign In for Pricing
View Details 288321-01 25 mg
3-Pyridin-4-Ylmethylpiperidine-3-Ethylcarboxylate Dihydrochloride
Sign In for Pricing
View Details