What is the catalog number for EGFR/CA-IX-IN-1?

The catalog number for EGFR/CA-IX-IN-1 is T210828.

What sizes are available for EGFR/CA-IX-IN-1?

EGFR/CA-IX-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does EGFR/CA-IX-IN-1 come in?

EGFR/CA-IX-IN-1 is available in 2 different pack sizes.

Is EGFR/CA-IX-IN-1 in stock?

EGFR/CA-IX-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGFR/CA-IX-IN-1?

EGFR/CA-IX-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for EGFR/CA-IX-IN-1?

Estimated delivery time for EGFR/CA-IX-IN-1 is approximately 10 business day(s), depending on your location.

EGFR/CA-IX-IN-1

Product Specifications

Target

Caspase, EGFR, Carbonic Anhydrase

Related Pathways

Apoptosis, Proteases/Proteasome, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Metabolism

Bioactivity

EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor of epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX), with IC50 values of 5.92 nM and 63 nM, respectively. This compound exhibits significant cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM. Additionally, EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, increases the BAX/Bcl-2 ratio, activates caspases, and causes cell cycle arrest at the G1 phase. It shows potential for breast cancer research.