Cholesterol 24-hydroxylase-IN-3

Cholesterol24-hydroxylase-IN-3 is an orally bioavailable, selective, brain-penetrant CH24H inhibitor (IC50 = 23 nM), classified as a 1,3-oxazole derivative. It inhibits CH24H enzyme activity competitively by coordinating the 1,3-oxazole nitrogen atom with the heme iron, with the cyclopropyl group occupying a hydrophobic pocket. Cholesterol24-hydroxylase-IN-3 has potential applications in research on neurological disorders like epilepsy.