MD-4251
Product Specifications
Target
PROTACs, Casein Kinase, MDM-2/p53, IKZF
Related Pathways
PROTAC, Metabolism, Stem Cells, Apoptosis, Immunology/Inflammation
Bioactivity
MD-4251 is an orally active MDM2 PROTAC degrader. It potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and activates p53. MD-4251 exhibits strong antiproliferative activity against acute leukemia cells with wild-type p53, but shows limited efficacy in mutant cells. In RS4;11 xenograft mouse models, MD-4251 induces complete tumor regression.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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