PROTAC PI3K/110β degrader-2
Product Specifications
CAS Number
3070438-79-5
Target
Apoptosis, PROTACs, Bcl-2 Family, Akt, ATPase, PI3K, P-gp, ROS
Related Pathways
Neuroscience, Membrane transporter/Ion channel, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, PROTAC, Apoptosis
Bioactivity
PROTACPI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. It effectively degrades the 110β protein and inhibits the expression of P-glycoprotein. Additionally, it increases reactive oxygen species (ROS) levels. PROTACPI3K/110β degrader-2 exerts antitumor effects by activating the endoplasmic reticulum stress (ERS) mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. This compound is applicable in cancer research.
Smiles
C(NC1=C(C(NCCCCCCC(N[C@H](C(=O)N2[C@H](C(NCC3=CC=C(C=C3)C=4SC=NC4C)=O)C[C@@H](O)C2)C(C)(C)C)=O)=O)C=CC=C1)(C)C=5C=6N(C(=O)C=C(N6)N7CCOCC7)C=C(C)C5
Molecular Formula
C51H65N9O7S
Molecular Weight
948.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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