PROTAC ERK5 degrader-1
Product Specifications
CAS Number
2919963-24-7
Target
PROTACs, ERK
Related Pathways
PROTAC, MAPK
Bioactivity
PROTACERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. It induces the degradation of ERK5 in MOLT-4 cells via a VHL-mediated proteasome pathway. PROTACERK5 degrader-1 is useful for studying diseases or disorders characterized by abnormal ERK5 activity.
Smiles
C(=O)(N1CCC(C=2C3=C(C=C(C=C3)N4CCN(CCCCCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5)C(C)(C)C)=O)CC4)N=CN2)CC1)C8=C(N)C=C(OC(F)(F)F)C=C8
Molecular Formula
C54H67F3N10O6S
Molecular Weight
1041.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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