Antitrypanosomal agent 26
Product Specifications
CAS Number
2601665-22-7
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
Antitrypanosomal agent 26 (Compound 1) is an allosteric inhibitor of trypanosome alternative oxidase (TAO) . It exhibits potent activity against African trypanosomes, such as Trypanosoma brucei, with an IC50 value of 1.3 nM for recombinant TAO. The compound disrupts the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 shows potential for research in treating African animal trypanosomiasis, including bovine trypanosomiasis.
Smiles
[Br-].O=C(OCCCCCCCCCCCCCC[P+](C1=NC=CC=C1)(C=2C=CC=CC2)C=3C=CC=CC3)C4=CC=C(O)C=C4C
Molecular Formula
C39H49BrNO3P
Molecular Weight
690.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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