DW34
Product Specifications
CAS Number
2758171-54-7
Target
Necroptosis, Epigenetic Reader Domain
Related Pathways
Apoptosis, Chromatin/Epigenetic
Bioactivity
DW34 is an orally bioactive pan-BRD4-D1-biased inhibitor that also exhibits BRD4-D2 activity. It demonstrates a low nanomolar inhibitory effect comparable to I-BET151 (EC50 value of 0.16 μM), with an EC50 value of 0.14 μM. DW34 significantly alleviates lipopolysaccharide (LPS) -induced liver inflammation and acetaminophen (APAP) -induced toxicity by reducing chemokine expression and cell necrosis.
Smiles
N1=NN(C(C=2N=C(OC=3C=C(C=C(C3)C)C)C=CC2)=C1C)C4CCN(CCN(C)C)CC4
Molecular Formula
C25H34N6O
Molecular Weight
434.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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