VU0514009
Product Specifications
CAS Number
932973-77-8
Target
Chemerin Receptor
Related Pathways
GPCR/G Protein
Bioactivity
VU0514009 is a competitive antagonist of chemokine-like receptor 1 (CMKLR1) with an EC50 of 2 nM. It effectively inhibits chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux responses in HEK293 cells. This compound shows potential for research in inflammatory diseases and metabolic syndrome.
Smiles
O=C1NC(=NC=C1S(=O)(=O)C2=CC=C(C(Cl)=C2)C)SCC(=O)NC3=CC(=CC=C3OC)C
Molecular Formula
C21H20ClN3O5S2
Molecular Weight
493.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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