ZAK-IN-1
Product Specifications
CAS Number
2362525-64-0
Target
MAPK
Related Pathways
MAPK
Bioactivity
ZAK-IN-1 is an orally active and selective inhibitor of the leucine zipper and sterile-alpha motif kinase ZAK, with an IC50 of 4 nM and a KD of 8 nM. It demonstrates exceptional selectivity against 403 types of wild-type kinases. ZAK-IN-1 effectively blocks the p38/GATA-4 and JNK/c-Jun signaling pathways, significantly suppressing cardiac hypertrophy. This compound is applicable in the study of hypertrophic cardiomyopathy (HCM) .
Smiles
O=S(=O)(NC1=CC=C(F)C(=C1F)N2N=NC(=C2)C=3C=NC=4NN=C(OC)C4C3)C5=CC=CC(=C5)C=6C=CC=CC6
Molecular Formula
C27H19F2N7O3S
Molecular Weight
559.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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