Nav1.8-IN-20

Nav1.8-IN-20 (Compound I) is an orally active inhibitor of the voltage-gated sodium channel Nav1.8, with an IC50 value of 14 nM. It effectively blocks the generation and propagation of action potentials in peripheral nociceptive neurons, providing analgesic effects. Nav1.8-IN-20 shows potential for research in several pain types, including acute, chronic, inflammatory, and neuropathic pain.