GSK-3β/HDAC-IN-2
Product Specifications
Target
Microtubule Associated, GSK-3, HDAC
Related Pathways
Stem Cells, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Cytoskeletal Signaling
Bioactivity
GSK-3β/HDAC-IN-2 is a potent inhibitor of GSK-3β (IC50 = 0.04 μM), HDAC2 (IC50 = 1.05 μM, Ki = 0.070 μM), and HDAC6 (IC50 = 1.52 μM, Ki = 0.017 μM) . It effectively inhibits HDAC2 and HDAC6 activities and prevents the hyperphosphorylation of tau protein. GSK-3β/HDAC-IN-2 demonstrates neuroprotective properties without significant toxicity and is useful for Alzheimer's disease research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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