What is the catalog number for PI3K/mTOR-IN-17?

The catalog number for PI3K/mTOR-IN-17 is T210742.

What sizes are available for PI3K/mTOR-IN-17?

PI3K/mTOR-IN-17 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does PI3K/mTOR-IN-17 come in?

PI3K/mTOR-IN-17 is available in 2 different pack sizes.

Is PI3K/mTOR-IN-17 in stock?

PI3K/mTOR-IN-17 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PI3K/mTOR-IN-17?

PI3K/mTOR-IN-17 is manufactured by Molfinity.

What is the estimated delivery time for PI3K/mTOR-IN-17?

Estimated delivery time for PI3K/mTOR-IN-17 is approximately 10 business day(s), depending on your location.

PI3K/mTOR-IN-17

Product Specifications

Target

PI3K, Apoptosis, Caspase, Bcl-2 Family, MDM-2/p53, mTOR

Related Pathways

Apoptosis, PI3K/Akt/mTOR signaling, Proteases/Proteasome

Bioactivity

PI3K/mTOR-IN-17 is a dual inhibitor that targets both PI3K and mTOR, with IC50 values of 1.21 μM and 0.21 μM, respectively. It induces apoptosis mediated by caspases and arrests cell growth in the G1 phase. The compound elevates the levels of caspases-3, 7, 8, and 9, enhances p53 expression, and increases the Bax/Bcl-2 ratio. By inhibiting the PI3K/mTOR signaling pathway, PI3K/mTOR-IN-17 is applicable in cancer research, including studies on non-small cell lung cancer (NSCLC) .