What is the catalog number for NLRP3-IN-81?

The catalog number for NLRP3-IN-81 is T210731.

What sizes are available for NLRP3-IN-81?

NLRP3-IN-81 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does NLRP3-IN-81 come in?

NLRP3-IN-81 is available in 2 different pack sizes.

Is NLRP3-IN-81 in stock?

NLRP3-IN-81 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures NLRP3-IN-81?

NLRP3-IN-81 is manufactured by Molfinity.

What is the estimated delivery time for NLRP3-IN-81?

Estimated delivery time for NLRP3-IN-81 is approximately 10 business day(s), depending on your location.

NLRP3-IN-81

Product Specifications

CAS Number

2922814-85-3

Target

Interleukin, Caspase, Pyroptosis, NOD-like Receptor (NLR)

Related Pathways

Apoptosis, Immunology/Inflammation, Proteases/Proteasome

Bioactivity

NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.