NLRP3-IN-81
Product Specifications
CAS Number
2922814-85-3
Target
Interleukin|||Caspase|||Pyroptosis|||NOD-like Receptor (NLR)
Related Pathways
Apoptosis|||Immunology/Inflammation|||Proteases/Proteasome
Bioactivity
NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 ?M for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1? release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
Smiles
O=S(=O)(C1=NN=C(C=C1)C=2C=CC(=CC2O)C(F)(F)F)C3CCCC3
Molecular Formula
C16H15F3N2O3S
Molecular Weight
372.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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