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CDK4-IN-3

Product Specifications

CAS Number

3002399-75-6

Target

Apoptosis, CDK

Related Pathways

Cell Cycle/Checkpoint, Apoptosis

Bioactivity

CDK4-IN-3 (Compound 389) is a highly selective irreversible inhibitor of cyclin-dependent kinase 4 (CDK4) with an IC50 of 25 nM and exhibits more than 10-fold selectivity over CDK6. It arrests the cell cycle at the G1 phase and induces apoptosis in tumor cells. CDK4-IN-3 holds potential for research in solid tumors such as breast and lung cancer.

Smiles

C(C)(C)N1C=2C(C(=O)C(C)=C1C3CCCN3)=CC=C(C2)C4=NC(N[C@H]5[C@H](O)COCC5)=NC=C4F

Molecular Formula

C26H32FN5O3

Molecular Weight

481.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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