CDK4-IN-3
Product Specifications
CAS Number
3002399-75-6
Target
Apoptosis|||CDK
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis
Bioactivity
CDK4-IN-3 (Compound 389) is a highly selective irreversible inhibitor of cyclin-dependent kinase 4 (CDK4) with an IC50 of 25 nM and exhibits more than 10-fold selectivity over CDK6. It arrests the cell cycle at the G1 phase and induces apoptosis in tumor cells. CDK4-IN-3 holds potential for research in solid tumors such as breast and lung cancer.
Smiles
C(C)(C)N1C=2C(C(=O)C(C)=C1C3CCCN3)=CC=C(C2)C4=NC(N[C@H]5[C@H](O)COCC5)=NC=C4F
Molecular Formula
C26H32FN5O3
Molecular Weight
481.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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