PRMT7-IN-2
Product Specifications
CAS Number
3058094-83-7
Target
Apoptosis, Histone Methyltransferase
Related Pathways
Apoptosis, Chromatin/Epigenetic
Bioactivity
PRMT7-IN-2 (A33) is a selective inhibitor of PRMT7 with an IC50 value of 0.50 μM. It causes cell cycle arrest at the G0/G1 phase, induces apoptosis, and inhibits cell growth both in vivo and in vitro. PRMT7-IN-2 reduces monomethylation levels of arginine by PRMT7, increases the expression of the epithelial marker E-cadherin, and decreases the expression of mesenchymal markers N-cadherin, Vimentin, and ZEB2.
Smiles
N1=C(N=C(NC=2C=CC=3N=C(C=C(N)C3C2)C)C=4SC=CC14)C5=CC(OC)=C(OC)C(OC)=C5
Molecular Formula
C25H23N5O3S
Molecular Weight
473.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
