Hsp90-Cdc37-IN-4
Product Specifications
CAS Number
2758818-41-4
Target
HSP, Apoptosis, Casein Kinase
Related Pathways
Cytoskeletal Signaling, Apoptosis, Stem Cells, Metabolism
Bioactivity
Hsp90-Cdc37-IN-4 is a novel derivative of triptolide that inhibits the protein-protein interaction (PPI) between Hsp90 and Cdc37. It selectively inhibits casein kinase 2 (CK 2), reducing the phosphorylation of its substrate Cdc37 at the serine 13 site. Additionally, Hsp90-Cdc37-IN-4 induces cell cycle arrest in the G0/G1 phase and triggers apoptosis via the mitochondrial pathway. This compound exhibits significant anti-breast cancer activity.
Smiles
C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(NCCCOC(/C=C/C4=CC=CC=N4)=O)=O)(C)C3)[H])CC[C@]5(C)C2=CC=C6C5=CC(=O)C(O)=C6C
Molecular Formula
C40H50N2O5
Molecular Weight
638.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal CYP51A1 Antibody (N6-P2H5/G8) [DyLight 650]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-50216C 0.1 mL
Mouse Monoclonal CYP51A1 Antibody (N6-P2H5/G8) [DyLight 650]
Sign In for Pricing
View Details 
26894066 1.0 µg DNA
LMAN1L Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details