Hsp90-Cdc37-IN-4
Product Specifications
CAS Number
2758818-41-4
Target
HSP|||Apoptosis|||Casein Kinase
Related Pathways
Cytoskeletal Signaling|||Apoptosis|||Stem Cells|||Metabolism
Bioactivity
Hsp90-Cdc37-IN-4 is a novel derivative of triptolide that inhibits the protein-protein interaction (PPI) between Hsp90 and Cdc37. It selectively inhibits casein kinase 2 (CK 2), reducing the phosphorylation of its substrate Cdc37 at the serine 13 site. Additionally, Hsp90-Cdc37-IN-4 induces cell cycle arrest in the G0/G1 phase and triggers apoptosis via the mitochondrial pathway. This compound exhibits significant anti-breast cancer activity.
Smiles
C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(NCCCOC(/C=C/C4=CC=CC=N4)=O)=O)(C)C3)[H])CC[C@]5(C)C2=CC=C6C5=CC(=O)C(O)=C6C
Molecular Formula
C40H50N2O5
Molecular Weight
638.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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