ELQ-121
Product Specifications
CAS Number
1228283-36-0
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
ELQ-121 is a potent inhibitor of the ubiquinol oxidation (QO) site in parasites. It exhibits an in vitro IC50 of 0.05 nM against both chloroquine-sensitive and multi-drug resistant Plasmodium falciparum. ELQ-121 also inhibits Toxoplasma gondii and Neospora caninum with an in vitro IC50 of less than 1 nM. It hinders the proliferation of Bacteroides fragilis tachyzoites with an IC50 of 0.49 nM and induces mitochondrial disruption. Furthermore, ELQ-121 can be formulated into a polyethylene glycol carbonate prodrug, which shows efficacy against P. yoelii in mice. ELQ-121 is applicable for antimalarial research.
Smiles
O=C1C=2C(F)=CC(F)=CC2NC(=C1CCCCCCC)C
Molecular Formula
C17H21F2NO
Molecular Weight
293.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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