MM-206

MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines[1].

Product Specifications

CAS Number

[1809581-87-0]

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mm-206.html

Purity

99.9

Solubility

DMF : 25 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=C(C(F)=C(C(F)=C1F)F)F)(NC2=C3C=CC=CC3=C(C(SC4=CC=CC=C4)=C2)O)=O

Molecular Formula

C22H12F5NO3S2

Molecular Weight

497.46

References & Citations

[1]A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment. Blood.2015 Dec 3.126 (23) : 569.