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PD-L1/HDAC3-IN-1

Product Specifications

Target

HDAC, PD-1/PD-L1

Related Pathways

Chromatin/Epigenetic, Apoptosis, Immunology/Inflammation, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

Bioactivity

PD-L1/HDAC3-IN-1 (PH3) is a dual inhibitor of PD-L1 and HDAC3, exhibiting IC50 values of 89.4 nM for PD-1/PD-L1 and 107 nM for HDAC3. It induces apoptosis and arrests the cell cycle in the G0/G1 phase. PD-L1/HDAC3-IN-1 demonstrates anticancer activity both in vitro and in vivo.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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