ZSH-2117
Product Specifications
Target
PROTACs, Akt, ERK, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, MAPK, Cytoskeletal Signaling, Angiogenesis, PROTAC, PI3K/Akt/mTOR signaling
Bioactivity
ZSH-2117 is a covalent and selective EGFR PROTAC degrader, with a DC50 of 45 nM in Ba/F3-EGFR[L858R/T790M/C797S] cells. It significantly inhibits cell proliferation and reduces AKT and ERK protein levels in downstream EGFR signaling pathways. ZSH-2117 effectively suppresses tumor growth in Ba/F3-EGFR[L858R/T790M/C797S] xenograft mouse models.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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