WEE1-IN-12
Product Specifications
CAS Number
3069940-37-7
Target
Wee1
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. It inhibits the proliferation of HT29 cells (IC50: 1.07 μM) and shows enhanced efficacy when combined with Gemcitabine (IC50: 0.34 μM) . WEE1-IN-12 is applicable in the study of tumors such as colon cancer.
Smiles
O=C(NC=1C(Cl)=CC=CC1Cl)C2=CN=C(N=C2OC3CC3)NC=4C=NN(C4)C5CCN(CCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5
Molecular Formula
C38H38Cl2N10O6
Molecular Weight
801.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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