Y040-7904

Product Specifications

Target

PTEN, Mitophagy, Beta Amyloid

Related Pathways

PI3K/Akt/mTOR signaling, Neuroscience, Autophagy

Bioactivity

Y040-7904 is a potential mitochondrial autophagy activator. It enhances mitochondrial autophagy by facilitating the transport of mitochondria to autophagosomes and promoting the fusion of autophagosomes with autolysosomes. Y040-7904 induces mitochondrial autophagy through the SIRT1/FoxO3 pathway and upregulates the levels of Parkin, PINK1, and LC3II/I. Additionally, Y040-7904 reduces Aβ accumulation in both in vitro and in vivo Alzheimer's disease models.