A2AR modulator-1
Product Specifications
CAS Number
3007566-23-3
Target
Adenosine Receptor
Related Pathways
Neuroscience|||GPCR/G Protein
Bioactivity
A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.
Smiles
N#CC1=C(N=C(C(C#N)=C1C=2C=CC=C(C2)C3=CN=CC=C3)N4CCCCC4)N
Molecular Formula
C23H20N6
Molecular Weight
380.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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