FLT3-IN-31
Product Specifications
CAS Number
2290545-53-6
Target
FLT, Apoptosis
Related Pathways
Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
FLT3-IN-31 (compound 10q) is a potent FLT3 inhibitor, with IC50 values of 0.16 nM for FLT3 and 2.4 nM for FLT3-D835Y, exhibiting antiproliferative activity. It reduces protein expression of p-FLT3, P-STAT5, and P-ERK. Additionally, FLT3-IN-31 induces apoptosis and causes cell cycle arrest at the G1 phase, displaying antitumor properties.
Smiles
C(=C/C1=CC(F)=C(CN2CCOCC2)C=C1)\C=3C=4C(=CC(=CC4)C=5C=C(N)N=CC5)NN3
Molecular Formula
C25H24FN5O
Molecular Weight
429.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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